The H2Optx mPAT LAB 3D chemical imaging of solid dosage
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The industry’s only solution for full 3D chemical imaging of solid dosage formulations. The H2Optx mPAT LAB integrates Raman spectroscopy, UV & VIS light spectroscopy, microscopy, hi-res optical imaging with automated X-Y-Z surface scanning.
The industry’s only solution for full 3D chemical imaging of solid dosage formulations
The H2Optx mPAT LAB integrates Raman spectroscopy, UV & VIS light spectroscopy, microscopy, hi-res optical imaging with automated X-Y-Z surface scanning.
This seamless integration, combined with H2Optx robotics & native sampling accessories, enables novel capabilities for the 3D characterization of powders, tablets, cells, vials, liquids, and emulsions.
FULL INTEGRATED ANALYTICAL METHODS
SPECTROSCOPY
- RAMAN
- Chemical composition & structure
- Organic & inorganic compounds
- Minimal or no sample preparation
- Measures <1µm to cm sample sizes
- Non-destructive
- Analyze in aqueous suspensions
- Analyze through transparent containers
- Combines well with other analytical methods
- UV
- ID materials that auto-fluoresce
- ID materials with weak to no Raman scattering
- High resolution image capture
- Quick
- VIS
- Capture hi-res color images
MICROSCOPY
- 5X
- 5X with UV & VIS
- Large field of view & rapid scanning of complex powders, tablets, liquids and emulsions
- 50X
- Used with VIS for submicron resolution
- Enables 3D structure mapping with Z-Scan
H2OPTX ROBOTICS
- Best-in-class Raman image acquisition speed
- Enables 4 x 4 x 4(mm) rapid scans
- X-Y-Z surface & 3D imaging
- Auto focus
- Imaging into liquids
HI-RES OPTICAL IMAGING
- Up to 60 frames per second
- Optical map for quick analysis of “hot spots”
- Single-pixel chemical analysis for immediate data processing
ADDITIONAL FEATURES
- IP65 rated for clean-in place applications
- Compatible with a full line of native sampling accessories
- Powered by a customizable, legacy-free and user-friendly software suite
SMALL MOLECULE
- Characterization of solid dosage and powder formulations
- Identify API & component concentrations down to .0001% by weight
- Particle size distribution by component
- Nearest neighbor, long-scale correlation, and coverage percentage analysis
- Prediction of dissolution profile from the solid form
- Process and product development for API synthesis and drug & media
formulations - New product line validation
- Technical troubleshooting
LARGE MOLECULE
- Accurately ID majority of culture media components
- Identify variability between media lots
- Identify differences in raw source materials
- Detect impurities within the raw materials
- Detect trace materials within complex powders
- Create particle size distribution maps to ID possible de-mixing effects
- Incoming QC inspection
- Archive samples for QA investigations
| Pillerator | Platerator | |
|---|---|---|
 |
 |
|
| The H2Optx Pillerator interfaces with the mPAT LAB to provide automated sectioning (5–500µm layer thickness) of solid dosage formulations. Hyperspectral scans of each layer are used to construct a 3D chemical map and structural analysis of a tablet or solid analyte. | The H2Optx Platerator interfaces with the mPAT LAB to enable fast, multi-axis Raman, UV and hi-res optical scans of complex powders, solids, and emulsions. Large, statistically significant sample sizes provide meaningful structural & chemical analysis for the Life Sciences and Fine Chemical industries. |
| Phase | |
|---|---|
| Technique | Raman, Spectrometer, UV, VIS |
| Industry | Chemical, Pharmaceutical |
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